9/19/2023 0 Comments Matters of life and death ck2![]() ![]() Pharmacological downregulation of CK2 activity by a panel of specific inhibitors, or knockdown of CK2 α expression by RNA interference, were able to induce cell death in R-CEM. We found that, while the CK2 regulatory subunit β was equally expressed in the two cell variants, CK2 α catalytic subunit was higher in R-CEM and this was accompanied by a higher phosphorylation of endogenous protein substrates. ![]() ![]() We investigated its possible involvement in the multidrug resistance phenotype (MDR) by analysing its level in two variants of CEM cells, namely S-CEM and R-CEM, normally sensitive or resistant to chemical apoptosis, respectively. Protein kinase CK2 is an ubiquitous and constitutively active kinase, which phosphorylates many cellular proteins and is implicated in the regulation of cell survival, proliferation and transformation.
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